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Raid Shadow Legends Pythion Guide

Introduction: Pythion – The Support Powerhouse

Raid Shadow Legends Pythion - Introduction: Pythion – The Support Powerhouse image
Pythion Ratings
Campaign
Arena Defense
Arena Offense
Clan Boss
Hydra
Faction Wars

Raid Shadow Legends Pythion, a must-fuse from early 2023, is one of the most praised support Champions in Raid. With a five-star rating in Faction Wars and universal utility, he’s often considered the best Fusion ever—offering top-tier cleanse, healing, and block debuffs that rival even Duchess Lilitu in certain situations.

Pythion’s Core Abilities (His Kit)

Raid Shadow Legends Resistance Aura

Resistance Aura

Pythion provides an Ally Resistance aura of 60 in all battles, which is quite valuable. “All battles” auras are particularly nice because they work in newer content like The Siege game mode.

Raid Shadow Legends Rapacious Staff

Rapacious Staff

Attacks one enemy twice, healing the lowest HP ally by 5% of Pythion’s Max HP per hit (10% total). The heal target can change mid-skill, and the double hit is great for Fire Knight.

Raid Shadow Legends Shed Skin

Shed Skin

Cleanses all allies, heals 10% of their Max HP plus 5% per debuff removed, then places Block Debuffs for 2 turns. Strong crowd control counter on a 3-turn cooldown.

Raid Shadow Legends Immortal Serpent

Immortal Serpent

Revives all dead allies with 50% HP and Turn Meter, then places Strengthen on the team for 2 turns. Only used when allies are dead.

Raid Shadow Legends Overlay

Overlay

Allies take 5% less skill damage per buff (up to 25%). Always active, stacks with other buffs like Strengthen, and excels in all content. Best paired with strong buffers.

Masteries: Optimizing Pythion’s Performance

Raid Shadow Legends Pythion - Masteries: Optimizing Pythion's Performance image
Combat Mastery Breakdown
Offense Defense
  • Deadly Precision
  • Keen Strike
  • Heart of Glory
  • Life Drinker
  • Single Out
  • Bring it Down
  • Methodical
  • Warmaster
  • Tough Skin
  • Blastproof
  • Resurgent
  • Delay Death
  • Solidarity
  • Retribution
  • Deterrence

Blessings

Raid Shadow Legends Pythion Guide - Raid Shadow Legends Blessing Polymorph
Raid Shadow Legends Pythion Guide - Raid Shadow Legends Blessing Brimstone

Recommended Blessings

Polymorph

This effect has up to a 20% chance to place a [Sheep] debuff on enemy Champions for 2 turns when they place debuffs on this champion or steal/remove buffs. It can trigger once per turn, can't be blocked, and doesn’t affect bosses. Sheeped enemies lose their skills, have 150 Speed, and revert with 50% HP and no buffs. At level 6, it no longer requires Accuracy.

Brimstone

Each hit from this champion has a chance to place a [Smite] debuff for 2 turns, dealing 25% max HP damage when the enemy uses an Active Skill and 5% to all other enemies. Only one enemy can have [Smite] at a time (4-turn cooldown). The chance increases with skill level: 15% at Level 1, 30% at Level 3, 60% protected at Level 5, and 100% protected and unresistable at Level 6.

Artifact Sets

Artifact Recommendations

Stoneskin

Gear

The Stoneskin Set, obtained from the Hydra Clan Boss, is considered the best PvP gear in the game. While active, it makes the wearer nearly immune to damage, blocks debuffs, and prevents Turn Meter manipulation. Only a few skills, like Warlord’s cooldown ability, can bypass it. For serious Arena play, farming Hydra for this set is essential.

Speed

Gear

Speed is one of the most important stats in Raid Shadow Legends, whether you're playing PvE or PvP, making the Speed Set one of the most valuable in the game. Early on, you can farm this set from Stage 6 of the Campaign, and as you progress, you’ll shift to farming it in the Dragon’s Lair. Acquiring good Speed gear is often one of your first major farming priorities.

Immortal

Gear

This set, rewarded for defeating the Clan Boss or Demon Lord, boosts survivability and damage for HP-based champions and provides alternative healing to sustain damage.

Building Pythion: Stats and Gear Priorities

Champion Stats Breakdown

Stat Value
HP 21,135
Attack 870
Defense 1,299
Speed 105
Critical Rate 15%
Critical Damage 50%
Debuff Resistance 50
Debuff Accuracy 0

When building Pythion, your stat priority should heavily lean towards survivability and speed. You'll want to focus on HP, Defense, Speed, and Resistance. Given his base Attack of 870, he's not a damage dealer, so you can completely forego Attack, Crit Rate, Crit Damage, and Accuracy. This makes building him relatively easier.

Conclusion: Why Pythion Is a Must-Have Champion

Pythion is an invaluable addition to any Raid: Shadow Legends account, capable of significantly boosting your team's survivability and utility across almost all content. His unique combination of cleanse, revive, and damage mitigation through his passive makes him a true game-changer.

Frequently Asked Questions (F.A.Q.)

❓ Is Pythion worth building?

Yes, absolutely. Pythion is one of the best support Champions in the game and widely considered the best Fusion ever released.

❓ Where is Pythion most useful?

Pythion is effective everywhere—Faction Wars, Arena, Hydra, Doom Tower, Clan Boss, and general PvE. His versatility makes him a staple in many team comps.

❓ What makes Pythion so strong?

He combines full-team cleanse, healing, revive, block debuffs, and passive damage reduction. His passive alone can reduce incoming damage by up to 25%.

❓ Is Pythion better than Duchess Lilitu?

In some scenarios, yes. Duchess offers Veil and Revive, while Pythion provides stronger cleansing and sustained healing. They're both top-tier, but Pythion can be better in cleanse-heavy situations.

❓ What gear sets work best on Pythion?

PVP: Stone Skin, Untouchable, Bolster
PVE: Relentless, Reflex, Regeneration
Stat priorities: HP, Speed, Defense, and Resistance.

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